CBD (Cannabidiol) for chronic pain, headache and migraine: comprehensive overview, current evidence.
This is an educational video on CBD (Cannabidiol) and its potential use for chronic pain, and headache disorders such as migraine. This was a lecture I did for our Cleveland Clinic Headache Center grand rounds. I get asked a lot of questions about CBD, so I am repeating it here, although I am doing it in a way which still remains partly scientific (for medical professionals), as well as put into layman’s term as much as possible for public education as well. This is not advice or recommendations. It is simply an educational overview based on currently available evidence and data. As scientific studies and updates occur with CBD, the video will be updated as well.
The sections are outlined below if you want to jump to a specific section/topic. However, my recommendation is to watch from beginning to end in order to gain the most comprehensive and up to date understanding of CBD.
00:00-7:20: Brief history of medical cannabis use for pain and headache, and transition to federally illegal Schedule 1 substance.
7:20-10:38: Review of endocannabinoid system, cannabinoid receptors and endocannabinoids.
10:38-18:54: Cannabis derived phytocannabinoids including CBD, CBD specific receptor actions, and their effects.
18:54-22:12: Neurobiology of cannabinoids and migraine.
22:12-26:36: Evidence for CBD in chronic pain and migraine.
26:36-34:08: CBD pharmacokinetics, safety information, adverse effects, and hemodynamic effects.
34:08-36:06: Legal overview of CBD.
36:06-42:37: Non-prescription over the counter CBD products including different categories of CBD products (full spectrum, broad spectrum, CBD isolate, etc.), product safety concerns, reasoning for need for independent 3rd party testing until FDA regulations available.
42:37-44:05: Clinical use suggestions; currently no standard dosing guidelines and this is widely variable between products.
44:05-47:27: Common CBD misconceptions.
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